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Studies show that NNMT inhibition by 5-amino-1-methylquinolinium significantly reduces nicotinamide metabolism, increases NAM accumulation, improves NAD+ synthesis efficiency by over 30%, and markedly increases mitochondrial ATP production and cellular energy metabolism
I., Jones, T
In the long-term studies conducted by Khavinson and his team, subjects followed for up to 15 years showed no significant toxicity or negative outcomes attributable to epithalon use
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