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there have been no reports of organ damage or severe reactions directly linked to NAD+ in clinical studies

Heliyon 6(5):e04102 Maluchenko NV, Feofanov AV, Studitsky VM (2021) PARP-1-associated pathological processes: inhibition by natural polyphenols

Due to its water-soluble nature, vitamin C can work both outside and inside the cells and can neutralize the free reactive species to avoid any damage

Filter-sterilize through a 0.22 m low-protein-binding membrane for sterile cell-culture workflows, and dilute into assay medium immediately before use to limit any extended bench-temperature exposure

10.1016/j.matpr.2023.09.135 22