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12,13 Although the original approval was largely based on the potent glucose-dependent insulinotropic properties of GLP-1R activation on pancreatic -cells, it has become clear that the GLP-1R is expressed on a variety of other tissues, which produce a range of biological effects across diverse organ systems (Figure 2)
That said, using GLP-1 medications off-label requires careful medical oversight to address potential side effects, nutritional needs, and fertility considerations
[PubMed: 40865172] Abdalla Ahmed MA, Ssemmondo E, Mark-Wagstaff C, Sathyapalan T
Discussion To discover therapeutic strategies that prevent tumor recurrence, we have focused on a unique trait of TICs, their capacity to grow within a 3D gel
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