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Nervous System The cytoprotective effects of FGF21, whether direct or indirect, are also evident in the nervous system, where FGF21 treatment attenuates neuroinflammation, neuronal oxidative stress, and neurodegeneration and preserves cognitive function in diabetic mice and high fat fed rats (270, 271)
Conversely, patients who progress during treatment despite an initial response exemplify the consequences of insufficient effector function
Scientific Reports (2021) 6
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