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The peptide has a very short plasma half-life of approximately 3 minutes, which influences dosing frequency and timing considerations
Tirzepatide targets two key receptors: GLP-1 and glucose-dependent insulinotropic polypeptide (GIP)
Tuka et al
The dose was started at 0.29 mg weekly and escalated every four weeks until the target dose was reached
However, their biological activity has been evaluated in only a limited number of cell lines and primarily through single metabolic assays, which limits the ability to draw clear conclusions about their mechanism of action and therapeutic potential
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