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The approved DPP-4 inhibitors demonstrate a high specificity toward DPP-4 and do not inhibit other peptidases
Importantly, the inhibition of BTK and SYK pathways, implicated in the amplification NF-B and MAPK-mediated inflammatory cascades and intersecting with the JAK/STAT network [246, 250], could support a translational link between B-cell-driven inflammation and attenuation of fibrosis in HS lesions
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While there are no reports of changes in MRS markers of oxidative stress, its role in long COVID gets support from studies showing elevated oxidative stress blood biomarkers [22]
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