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Enucleation, a rate-limiting step of erythrocyte maturation, is tightly regulated via coordination of multiple transcription factors (FOXO3, E2F2, etc.), miRNAs (miR-30a, miR-191, miR-181a), cytoskeleton proteins (F-actin, dynein, tropomodulin, etc.), and kinases (p38 MAPK, p38 mitogen-activated protein kinase) [33]

In parallel, health systems should consider commissioning large RWS to understand the full benefits of GLP-1s in routine use including outcomes in the many patients currently using these drugs out-of-pocket

Key Takeaways From This Blog: GLP-1 updates highlight growing use of these medications and their impact on employer health plans

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Profiling the gasdermin D-targeting proteases also illuminated why variants evolved on GD_Sh were able to pass PACE selection but failed to cleave longer gasdermin D substrates in vitro