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When sourced from a licensed pharmacy and used at proper doses, both peptides have favorable safety profiles

serious risks include pancreatitis and gallbladder disease, and neither is licensed by the MHRA, so use outside clinical trials is not supported

Watch for signs of dehydration that have nothing to do with thirst, like dark urine, headaches, and fatigue

Sustained body-composition research With Combined LEAP2 and Semaglutide investigation [PMID: 40590720] Laboratory literature summary: Sustained body-composition research With Combined LEAP2 and Semaglutide investigation in Mice

For a detailed look at what side effects can look like with other compounds in this class, see the breakdown on cagrilintide peptide side effects