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The TRIPS Agreement (Trade-Related Aspects of Intellectual Property Rights) allows countries to issue compulsory licenses to manufacture or import generic versions of patented drugs in certain public health emergencies or other circumstances [41]

With these antioxidant and AMPK-activating actions, berberine is thought to provide several health benefits, from lowering blood sugar and cholesterol to promoting weight loss and brain functionlets take a closer look

In hemodialysis patients, due to reduced renal clearance, carnitine depletion and acylcarnitine accumulation become significant, resulting in an abnormal increase in the ratio of acylcarnitine to free carnitine in plasma, which in turn inhibits cardiac fatty acid metabolism [261]