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Published Literature on Combined Peptide Protocols While dedicated head-to-head or combination human clinical trials are not yet available, a growing body of pre-clinical rodent research supports the mechanistic basis for studying these peptides together

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For instance: PRIMA-1 and its analog APR-246 covalently modify p53 mutants through the alkylation of thiol groups, restoring wild-type conformation and function to mutant p53 59