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Indian Journal of Public Health, 42 (1), 20-23
The peptide can influence gene expression, promoting a youthful phenotype by activating reparative processes in skin cells and reducing oxidative damage
Furthermore, the mechanistic significance of these pathways, mediated by PDE1B and PDE10A, has guided medicinal chemistry efforts, which, when integrated with computational approaches, have substantially accelerated the discovery of potent, selective, and CNS-penetrant PDE1B and PDE10A inhibitors (Bhardwaj and Purohit, 2021
Due to cereal fortification with folic acid, folate levels are more typically adequate, but B12 levels are often inadequate due to a lack of sensitivity in testing ( CMAJ 2005;172:1569-1573) as well as reduced B12 absorption through aging ( CMAJ 2004;171:251-259)
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