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The mechanisms behind B12 deficiency in metformin users are multifactorial but are probably related to intestinal absorption, so it seems sensible to assume that oral B12 replacement may be less effective, although there is little evidence in this area
For instance, supplementing aged mice with NMN, which increases NAD+, improved oocyte quality and embryo blastocyst rates
Its a short chain of amino acidswhat scientists call a peptideoriginally isolated from human gastric juice
(2021) 29:e3446
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