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Interestingly, PICs were shown to induce the expression of heme oxygenase-1 (HO-1), which promotes the release of free Fe 2+ into the cytoplasm and subsequently an increased mitochondrial accumulation of iron in cultured glial cells (76), thus contributing to increased generation of mitochondrial ROS

The study was focused on cardiovascular outcomes like heart attack and stroke and cancer, and it found no benefit from vitamin D compared to placebo, Bent said