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Unlike native IGF-1, the LR3 variant does not bind strongly to IGF Binding Proteins (IGFBPs)

While some consider tan temporary, leaving it untreated can lead to uneven tone, dark patches, and premature aging

Cosmetic effects like Ozempic face (a thinner, gaunt appearance from rapid fat loss in the face) and temporary hair shedding have also been reported

The M1 phenotype, stimulated by lipopolysaccharide (LPS) and interferon- (IFN-), was used as a positive control, whereas the M2 phenotype, induced by interleukin-4 (IL-4), functioned as a negative control