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Moreover, MAPK/ERK signaling upregulates Kruppel-like factor-2 (KLF2) and KLF4, which enhance eNOS expression, inhibit NF-B signaling, and suppress TNF- receptor expression, reinforcing anti-inflammatory and atheroprotective effects [207]

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Conclusions The results of this study indicate that low-dose (0.025 mg/kg) oral rapamycin, administered three times a week for one to five months to healthy, middle-aged large breed dogs, resulted in detectable concentrations of rapamycin in four dogs that was measurable in ng/ml

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