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Nausea, vomiting, diarrhea, and constipation are common during dose escalation
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Amifostine may also play a role in the protection of salivary glands and, thus leading to improvement of xerostomia
Bismah Irfan, MD As of May 2026, the standard semaglutide dosing schedule is a 16-week dose-escalation that starts at 0.25 mg once weekly and steps up every four weeks to a maintenance dose of either 1.0 mg (Ozempic, type 2 diabetes), 2.0 mg (Ozempic, intensified diabetes control), or 2.4 mg (Wegovy, chronic weight management)
1 In fact, the impact of GLP-1s is likely to be more nuanced than the blunt conclusions drawn by market watchers, with some companies and segments affected more than others
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