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The FDA has issued warnings to companies that have illegally sold drugs labeled for research purposes or not for human consumption. Some of these products have been sold directly to patients for human use, regardless of being specifically labeled not to be used in humans

Despite early conflicting results, further studies showed that insulin is excreted in urine

These findings are also interesting from an IGF-1R targeting point of view because pharmacological modulations leading to an excess of MDM2 could be a manner to cause a selective IGF-1 inhibition and apoptosis in cancer cells

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Funding This work was supported by Fundao para a Cincia e a Tecnologia FCT to AP (PD/BD/136887/2018)