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2) This comprehensive study performed by the research team of McCoy et al aimed to develop metabolically stable AngIV analogs with enhanced blood-brain barrier (BBB) permeability and procognitive activity, specifically focusing on a molecule named Dihexa

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This Notch downregulation reduces MHC-I expression and chemokine secretion, hindering T-cell infiltration and promoting immune escape

The clinical consequence ranges from local inflammation through to systemic hypersensitivity and antibody formation

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