Neurological Disorders Related to B12 Deficiency Vitamin B12 deficiency can cause problems like nerve damage, memory loss, and dementia
These effects are usually mild to moderate, occur most frequently when starting treatment or increasing doses, and often improve over time
This situation would lead to a self-perpetuating cycle, in which the free radicals generated would induce GSH depletion, thus increasing oxidative stress that would reduce antioxidant enzyme levels, which would further reduce GSH synthesis
As the C-termini of all zDHHCs except zDHHC24 face the cytosol, we hypothesized that the addition of a C-terminal KASH-domain might induce their targeting to the ONM (Fig
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