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This dual-compound approach targets multiple metabolic pathways simultaneously, which some patients find more effective than single-agent therapy

GLP-1 receptors are expressed on osteoblasts (bone-forming cells), and some animal studies suggest GLP-1 may actually support bone formation

This structure has been shown to improve peptide chemical stability and to extend in vivo activity 15,16 and could provide some stability benefit when in antibody fusion

Conversely, treatment of rats with the GIPR antagonist, rat GIP (330)NH2, does not modify food intake but significantly increases plasma TG and LPL compared with controls (Baldassano et al., 2019)

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