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acknowledges support from NIH K12 grant no
A-42 aggregates and combines to Ca 2+ channels and AMPA (-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors, to which the neurotransmitter glutamate binds, so A is the most neurotoxic form (3, 31)
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Developed by Eli Lilly, it is currently being evaluated in the Phase 3 TRIUMPH clinical trial program
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