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doi: 10.1016/j.jep.2021.114923 79 ShaoYYChangZPChengYWangXCZhangJPFengXJet al

Visceral fat dysfunctions in the rat social isolation model of psychosis (in Eng)

elegantly demonstrated that neural stem cell secretomes inhibit microglial activation via BDNF/VEGF signaling, but their work neglected gastrointestinal dysbiosis, overlooking the bidirectional crosstalk now recognized as central to ASD pathophysiology [42]

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A: The main reasons are limited drug-level clinical data, high FDA approval costs, and insufficient commercial incentives for pharmaceutical development