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Baseline data were determined at the time of randomization, including trials with a run-in period before randomization

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Data were analyzed using an ANOVA test (Prism 10 software) to compare HFD versus treated groups at W0 and W12 and HFD + Gliben + IF + exercise group and other treatment groups at the same time intervals

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The unit conversion for each half-dose: At 10 mg/mL: 3.75 divided by 10 equals 0.375 mL, or 37.5 units per injection At 20 mg/mL: 3.75 divided by 20 equals 0.1875 mL, or 18.75 units per injection Split dosing may reduce GI side effects by spreading the medication absorption over two peaks instead of one