Reaney M, Yu M, Lakshmanan M, Pechtner V, van Brunt K
Safety, adverse events, and how they factor into which medication may be right for you Common side effects of semaglutide and tirzepatide include: Nausea Vomiting Diarrhea Stomach pain Decreased appetite Indigestion Belching Constipation Headache Risk of low blood sugar Semaglutide and tirzepatide can cause serious side effects such as pancreatitis (inflammation of the pancreas), gallbladder problems, changes in vision, serious allergic reactions, and kidney issues
NICE guidance requires at least 5% weight loss after 6 months at maintenance dose for treatment continuation, with maximum recommended duration of 2 years
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Christensen B, Frosst P, Lussier-Cacan S, Selhub J, Goyette P, Rosenblatt DS, Genest J Jr, and Rozen R (1997)