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This can irritate and harm the esophageal lining, producing symptoms such as heartburn, chest pain, swallowing problems, food or acid regurgitation, coughing, voice hoarseness, throat soreness, and unpleasant breath
Topical formulations have also demonstrated measurable effects on pigmentation
In the nucleus, following heterodimer complex formation with transcription factors, like small Maf proteins (G/F/K) and c-Jun, Nrf2 complexes bind to the antioxidant response element (ARE), a regulatory enhancer region within gene promoters that upregulate antioxidant and anti-inflammatory defense processes (Cuadrado et al., 2019
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Studies were classified as High, Medium, or Low quality
