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While GGT5 and GGT1 share 40% of the amino acid sequence (22), GGT5 is not as active in hydrolyzing GSH, GSSG and leukotriene C4 as GGT1 is (29)
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In clinical studies, metformin therapy was associated with improved clinical outcomes, including reduced TB severity, and a lower incidence of latent TB infection (LTBI) [118]
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