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The PEN form is a technical choice, not a different molecule: the ready solution eliminates reconstitution and improves the repeatability of draws from a constant mg/ml concentration, in exchange for greater sensitivity to storage conditions and a shorter stability window after opening

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To study the comparison of systemic and localized effects in models of severe lesions or tendon-to-bone integration

For mild local reactions limited to the injection site without systemic symptoms: Discontinue the injection if still in progress Apply a cold compress to reduce swelling and discomfort Avoid rubbing or massaging the affected area Monitor for progression over the next 2-4 hours Contact your healthcare provider if symptoms worsen or persist beyond 24 hours Document the reaction, including timing, appearance, and duration Mild local reactions may not require treatment discontinuation, but medical evaluation is necessary to determine whether subsequent doses are safe