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Yes, semaglutide can contribute to fatigue in some patients, particularly during dose escalation or early weeks of therapy
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Side Effects of Tirzepatide (Mounjaro) Common side effects include: These effects are usually temporary and reduce as the dose is increased gradually
10.1210/jc.2015-2725 151
Additionally, GLP-1RAs facilitate the maintenance of endothelial barrier integrity, thus playing a crucial role in preventing vascular leakage.452 Endothelial cells exhibit enhanced NO production and concurrent suppression of endothelin formation, resulting in vascular smooth muscle relaxation and vasodilation mediated by the endothelium (e.g., GLP-1, exenatide, and liraglutide).453 Indeed, GLP-1RAs, including exenatide, liraglutide, and semaglutide, have been linked to the diminished expression of matrix metalloproteinases (MMPs).454,455,456 MMPs are a class of enzymes that play a crucial role in the breakdown of extracellular matrix components
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