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In ovarian cancer, ARG1, using extracellular vesicles as a carrier, inhibits T-cell proliferation, which is beneficial to tumor growth and immune escape (Czystowska-Kuzmicz et al., 2019)
Utility of in vitro bioactivity as a lower bound estimate of in vivo adverse effect levels and in risk-based prioritization
Borg CM, Le Roux CW, Ghatei MA, Bloom SR, Patel AG, Aylwin SJB
Here is a typical 13-week escalation protocol based on commonly prescribed dosing schedules
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