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Describing her experience maintaining her weight loss after stopping semaglutide, Shepherd said, "Absolutely people can get off of it and do it, and I wouldn't be scared to get off of it." Ashton said that some people with obesity may need to stay on a medication for weight loss "indefinitely." "We know that the phenomenon is set in the brain to restore your weight to its heaviest level, so this is not a matter of willpower