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found that the JA pathway inhibited the transcriptional activity of ICE1/2 via the JAZ protein and regulated the freezing tolerance of Arabidopsis thaliana [84]

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Thus, ADT is the frontline treatment and directed toward disruption of T-DHT-AR axis by suppression of gonadal T by medical or surgical castration ( de novo steroidogenesis, which involves upregulation of enzymes required for stepwise synthesis from cholesterol to T and DHT (111)