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The maximum dose tested in Phase 2 was 12mg once weekly, where 24.2% body weight loss was recorded at 48 weeks (Jastreboff et al., NEJM 2023)
Endothelial nitric oxide synthase-derived nitric oxide prevents dihydrofolate reductase degradation via promoting S-nitrosylation
Many other inhibitors/agonists may also be used
10.2174/1570159X19666201230144109 34
This bypasses all absorption barriers and ensures the antioxidant reaches target cells including melanocytes in clinically effective amounts
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