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FIGURE 10 Notably, activators of SIRT1, such as metformin, have demonstrated the ability to inhibit Th17 cell differentiation and downregulate IL-17A and RORt levels by promoting STAT3 deacetylation (Hamaidi and Kim, 2022)

GPX4 and GSH, as inhibitors of lipid peroxidation, are key regulators that control ferroptosis

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Severe gastroparesis or other serious GI motility disorders make tirzepatide problematic