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Above that threshold, additional methionine or choline doesn't compound the effect because the liver's methylation enzyme capacity is saturated
10.1056/NEJMsr1606602 32 LeeH.LeeY.KimJ.AnJ.LeeS.KongH.et al (2018)
The term took hold mostly because NAD+ is so often given in the same visit, or the same broader plan, as genuine peptides
So taking it at the same time every day (or weekly, if youre on a weekly injection) helps maintain steady levels and maximize effectiveness
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