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doi: 10.1016/j.neurobiolaging.2017.12.009 204 GumusluECineNErtanMMutluOKomsuoglu CelikyurtIUlakG

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In the LEADER trial, over 9,340 patients with type 2 diabetes and high cardiovascular disease risk underwent randomization to liraglutide or placebo and were followed for a median of 3.8 years resulting in a 13% risk reduction in a combined endpoint of death from cardiovascular cause, nonfatal myocardial infarction, or nonfatal stroke [46]

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Higher cumulative doses and high-dose regimens are associated with increased disease duration and risk of damage