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We speculated that GLP-1RA might regulate Treg cells with high expression of GLP-1R after activation, and exert anti-inflammatory effects by increasing anti-inflammatory factors such as IL-10

Tirzepatide suppresses palatable food intake by selectively reducing preference for fat in rodents In collaboration with Eli Lilly, we showed that the dual GLP-1/GIP agonist Tirzepatide robustly decreases preference for palatable foods by selectively decreasing lipid consumption

Clinical studies have shown that adults who took GLP-1 for 68 weeks have lost an average of 35 pounds

The integration between these datasets was assessed, and genes and lipids were mapped to relevant KEGG metabolic pathways for over-representation analysis, with significance determined by the False Discovery Rate (FDR)

T cells in the post-ischemic brain: Troopers or paramedics