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**Due to vial size limitations, Tiers 1, 2 and 3 plans will receive the same total mg, but will have different dosing instructions

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Methotrexate-induced hearing loss is often subtle and progressive, necessitating long-term auditory monitoring in patients receiving high-dose therapy (Moore et al

Comparative analysis showed that D-CuP exhibited higher binding affinities than its monomeric counterpart M-CuP, with Vina scores of -5.7 kcal/mol for p53 and -6.4 kcal/mol for HDAC7, compared to -4.2 kcal/mol and -4.8 kcal/mol for M-CuP, respectively (Fig