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The most abnormal thing here is the advisory committee overruling FDA scientists in a wholesale fashion, says Howard Sklamberg, an Arnold & Porter Life Sciences & Healthcare Regulatory partner and former deputy commissioner for Global Regulatory Operations and Policy at the FDA

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Strategic Exercise (Quality Over Quantity) Exercise prescription in perimenopause needs to change: Strength training priority: 3-4x/week focusing on progressive overload to combat muscle loss Strategic cardio: Less chronic cardio, more HIIT for metabolic benefit without cortisol spike Recovery emphasis: Adequate rest between sessions

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