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Maintaining a lower body weight over time often translates to a healthier metabolic profile and can thus potentially extend life expectancy
McGowan 2024)
Trial support is deep: STEP (semaglutide, NEJM 2021), SURMOUNT (tirzepatide, NEJM 2022), and SURMOUNT-OSA (tirzepatide in obstructive sleep apnea, NEJM 2024)
Semaglutide has been modified structurally to prevent it from being broken down by an enzyme in the blood called dipeptidyl peptidase-4 or DPP-4
As a result, unresolved shame or self-critical schemas may continue to influence emotional functioning, body image, and interpersonal behavioreven in the context of metabolic improvement
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