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relatively large apparent volume of distribution of ~2-3 L/kg in horse, cows, sheep & dogs reflecting its relatively high lipid solubility in dogs, xylazine is metabolized by the liver to ~20 metabolites, with only 8% eliminated unchanged in the urine, (Rector et al, 1996

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A single 9-tetrahydrocannabinol (THC) dose during brain development affects markers of neurotrophy, oxidative stress, ad apoptosis

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Under a stressful condition, keap1, a regulatory protein that binds to Nrf-2 in the cytoplasm, is deactivated