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J Biol Chem 282:1842736 Pineda-Molina E, Klatt P, Vazquez J, Marina A, Garcia DL (2001) Glutathionylation of the p50 subunit of NF-kappaB: a mechanism for redox-induced inhibition of DNA binding

Role of superoxide anion in the generation of other reactive species Superoxide anion (O2) which is constantly being generated through endogenous processes and exogenous sources can through different pathways or chain reactions cause the formation of several other reactive species.15 It can directly produce hydroxy radical (OH) (O2 + 2e OH) or indirectly from hydrogen peroxide which results from its dismutation by SOD (H2O2 + e OH), through Fenton reaction which occurs in the presence of Fe2+ (Fig