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In contrast, humans and animals, including rodent models, with congenital erythropoietic porphyria (due to uroporphyrinogen synthetase III deficiency) have a chronic hemolytic anemia as well as porphyrin accumulation with photosensitivity (Blouin et al 2020)

Thus, the mechanism responsible for the pericentral damage pattern of OTA still remains to be elucidated