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Cell 14 , 528536 (2011)
Irisin is another myokine produced in response to exercise, and regulates energy metabolism
What they found (summary): Development of Melanotan II as a cutaneous drug failed due to the combination of side effects Bifurcation into more selective derivatives was both scientifically and commercially successful PT-141 Bremelanotide (Vyleesi, 2019) Melanotan I Afamelanotide (Scenesse, 2014) Underground use of Melanotan II is safety-problematic Why it matters: This is the definitive historical review by the founders of the field
It exists in a regulatory grey area as a research chemical
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