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For the studies including assessments at multiple time-points, the data at baseline and immediately after the weight loss phase were extracted for the analysis
This represents the sweet spot where therapeutic effects strengthen without side effects becoming prohibitive
Suttrup I, Warnecke T
It has been hypothesized that during embryogenesis, somatic gene mutations can occur in healthy heterozygote individuals resulting in loss of heterozygosity (LOH) where the hamartomatous area presumably originates [23]
Even small deviations indicate synthesis problems or degradation
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