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Tirzepatides unique approach: Tirzepatide goes a step further by targeting two hormones, GLP1 and another called GIP
Given that the majority of patients with true HFpEF have a cardiometabolic phenotype, with very high prevalence of overweight or obesity, it is likely that the treatment approach in this patient population may ultimately include combination therapy with SGLT2 inhibitors and GLP-1 receptor agonists, given their nonoverlapping and complementary mechanisms of action
Results vary based on metabolism, diet, activity levels, and adherence to the Wegovy weight loss 3 months plan
doi: 10.3389/fendo.2023.1085799 16 UngerJRParkinCG
Proteasome inhibitors: bortezomib, carfilzomib
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