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Some of the most convincing human data supporting the pore and leak pathways were generated in normal humans given a low pro-inflammatory intravenous dose of bacterial endotoxin and PEGs of MW 40010,000 Da

Sondermann P, Huber R, Oosthulzen V, Jacob U (2000) The 3.2- crystal structure of the human IgG1 Fc fragment-FcRIII complex