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Ironically, a side effect of excessive anticholinesterase treatment is excessive weakness or cholinergic crisis due to excessive stimulation of nicotinic receptors in the muscle end-plate region, resulting in a transient phase of uncontrolled muscle fasciculations due to sustained depolarization, followed by the development of receptor desensitization and a flaccid paralysis
Pathogens, such as Pseudomonas aeruginosa that release pyocyanin, a nitrogen-containing aromatic compound, can also increase intracellular levels of superoxide and hydrogen peroxide
Indian J Exp Biol 40:12404, PMID:13677625 Morris G, Maes M (2013) Myalgic encephalomyelitis/chronic fatigue syndrome and encephalomyelitis disseminata/multiple sclerosis show remarkable levels of similarity in phenomenology and neuroimmune characteristics
But, if they dont or get worse, its important to talk to a doctor
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