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Type 1 contains vildagliptin and saxagliptin, which bind only to the S1 and S2 subsites and form a covalent bond with the nitrile group of their cyanopyrrolidine moiety and Ser630 of DPP-4

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1a) with DCFDA, a fluorescent sensor of hydrogen peroxide 40 , revealed increased ROS in B6 MZB compared to B6 FoB (Fig

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