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The net effect of Akt activation is a shift toward anabolism: more protein synthesis and less protein breakdown
In the study of the protective effect of trehalose on oxidative stress damage in sheep epididymal epididymal cells, it was again found that the upregulation of GPX5 plays a key role ( During epididymis transport, spermatozoa are vulnerable to intracellular and extracellular ROS attacks and rely on antioxidant scavengers synthesized by the epididymis for protection
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In vitro, NAC improved ifosfamide benefits by decreasing nephrotoxicity without reducing antitumor effects (26)
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