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Persistent stimulation leads to receptor desensitization
Additionally, exendin-4 reduced the macrophages uptake of oxLDL by activating GLP-1 receptor and as a consequence, reduced foam cell formation in vivo
Most studies suggest getting at least 500 mg per day
Metformin absorption may slow slightly, but the combination is generally well-tolerated when doses are adjusted appropriately
10.1001/jama.2025.6462 BMC Medicine
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